JPS5849352A - アルギニンバソプレシンの抗利尿及び／又は血圧上昇作用の新規な「きつ」抗剤 - Google Patents
アルギニンバソプレシンの抗利尿及び／又は血圧上昇作用の新規な「きつ」抗剤Info
- Publication number
- JPS5849352A JPS5849352A JP57044789A JP4478982A JPS5849352A JP S5849352 A JPS5849352 A JP S5849352A JP 57044789 A JP57044789 A JP 57044789A JP 4478982 A JP4478982 A JP 4478982A JP S5849352 A JPS5849352 A JP S5849352A
- Authority
- JP
- Japan
- Prior art keywords
- antidiuretic
- compound
- arginine
- acid
- valine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 title claims description 45
- 239000003160 antidiuretic agent Substances 0.000 title claims description 34
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- 238000000034 method Methods 0.000 claims description 20
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- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 claims description 6
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- SNDPXSYFESPGGJ-SCSAIBSYSA-N D-2-aminopentanoic acid Chemical compound CCC[C@@H](N)C(O)=O SNDPXSYFESPGGJ-SCSAIBSYSA-N 0.000 claims description 3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/15—Oxytocin or vasopressin; related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US247008 | 1981-03-24 | ||
| US06/247,008 US4367225A (en) | 1981-03-24 | 1981-03-24 | Novel antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin |
| US322071 | 1981-11-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5849352A true JPS5849352A (ja) | 1983-03-23 |
| JPH0325439B2 JPH0325439B2 (en]) | 1991-04-05 |
Family
ID=22933152
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57044789A Granted JPS5849352A (ja) | 1981-03-24 | 1982-03-23 | アルギニンバソプレシンの抗利尿及び／又は血圧上昇作用の新規な「きつ」抗剤 |
| JP62283225A Pending JPS63239297A (ja) | 1981-03-24 | 1987-11-11 | 新規な拮抗剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62283225A Pending JPS63239297A (ja) | 1981-03-24 | 1987-11-11 | 新規な拮抗剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4367225A (en]) |
| JP (2) | JPS5849352A (en]) |
| CS (1) | CS262407B2 (en]) |
| IN (1) | IN156510B (en]) |
| ZA (1) | ZA821422B (en]) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61172898A (ja) * | 1985-01-23 | 1986-08-04 | メデイカル カレツジ オブ オハイオ | アルギニンバソプレツシン拮抗薬の新規誘導体類 |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4491577A (en) * | 1981-11-16 | 1985-01-01 | The Medical College Of Ohio | Antagonists of the antidiuretic action of arginine vasopressin |
| US4504469A (en) * | 1982-12-21 | 1985-03-12 | Ferring Ab | Vasotocin derivatives |
| US4587045A (en) * | 1983-02-16 | 1986-05-06 | Smithkline Beckman Corporation | Intermediates for preparing octapeptide vasopressin antagonists |
| US4469679A (en) * | 1983-02-16 | 1984-09-04 | Smithkline Beckman Corporation | Octapeptide vasopressin antagonists |
| US4469680A (en) * | 1983-07-06 | 1984-09-04 | Smithkline Beckman Corporation | Iodinated vasopressin antagonists |
| US4551445A (en) * | 1983-10-14 | 1985-11-05 | The Medical College Of Ohio | Derivatives of arginine vasopressin antagonists |
| US4714696A (en) * | 1984-01-26 | 1987-12-22 | Medical College Of Ohio | Novel derivatives of arginine vasopressin antagonists |
| US4481193A (en) * | 1984-03-07 | 1984-11-06 | Smithkline Beckman Corporation | Des-proline vasopressin antagonists |
| US4481194A (en) * | 1984-03-07 | 1984-11-06 | Smithkline Beckman Corporation | Des-proline-des-glycine vasopressin antagonists |
| PH21037A (en) * | 1984-03-07 | 1987-06-30 | Smithkline Beckman Corp | Des-proline vasopressin antagonists |
| US4597901A (en) * | 1984-12-14 | 1986-07-01 | Smithkline Beckman Corporation | β-indolylalanyl or β-indolylglycinyl vasopressin antagonists |
| US4719199A (en) * | 1984-12-14 | 1988-01-12 | Smithkline Beckman Corporation | Diuretic compositions and methods of producing diuresis |
| US4684716A (en) * | 1984-12-14 | 1987-08-04 | Smithkline Beckman Corporation | Polypeptide intermediates |
| US4624943A (en) * | 1985-03-20 | 1986-11-25 | Smithkline Beckman Corporation | Aromatic basic-tailed vasopressin antagonists |
| US4656248A (en) * | 1985-04-23 | 1987-04-07 | Smithkline Beckman Corporation | Cupric oxidation of 1,6-dimercapto-containing peptides |
| US4711877A (en) * | 1985-09-18 | 1987-12-08 | Smithkline Beckman Corporation | 6-pen-vasopressin compounds |
| US4826813A (en) * | 1987-05-21 | 1989-05-02 | Smithkline Beckman Corporation | 4'-Methyl-β-mercapto-β,β-cyclopentamethylenepropionic acid vasopressin antagonists |
| US5055448A (en) * | 1987-06-25 | 1991-10-08 | Medical College Of Ohio | Linear derivatives of arginine vasopressin antagonists |
| US5225528A (en) * | 1990-02-27 | 1993-07-06 | Merck & Co., Inc. | Cyclic hexapeptide oxytocin antagonists |
| US20030103983A1 (en) * | 2002-05-09 | 2003-06-05 | Pressler Milton Lethan | Ace inhibitor-vasopressin antagonist combinations |
| US8168592B2 (en) * | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1193509B (de) * | 1960-06-02 | 1965-05-26 | Hoechst Ag | Verfahren zur Herstellung eines neuen Oktapeptids mit vasopressorischer Wirksamkeit |
| CH426861A (de) * | 1963-06-06 | 1966-12-31 | Sandoz Ag | Verfahren zur Herstellung eines bisher unbekannten Polypeptids |
| CH442342A (de) * | 1964-07-17 | 1967-08-31 | Sandoz Ag | Verfahren zur Herstellung eines neuen Polypeptids |
| CH460039A (de) * | 1965-04-15 | 1968-07-31 | Sandoz Ag | Verfahren zur Herstellung eines neuen Polypeptids |
| CH495957A (de) * | 1966-09-15 | 1970-09-15 | Ceskoslovenska Akademie Ved | Verfahren zur Herstellung eines antidiuretisch wirksamen Polypeptids |
| US3691147A (en) * | 1970-06-05 | 1972-09-12 | Medical College Of Ohio The | (4-l-threonine)-oxytocin |
| US3700652A (en) * | 1970-08-31 | 1972-10-24 | Medical College Of Ohio At Tol | (4-l-threonine)-mesotocin |
| ZA72790B (en) * | 1971-03-12 | 1972-10-25 | Kloeckner Werke Ag | Conveyor trough for scraper chain conveyors,particularly twin chain conveyors |
| US4148787A (en) * | 1976-05-24 | 1979-04-10 | Ferring Ab | Antidiuretically effective polypeptide and a process for preparing the same |
-
1981
- 1981-03-24 US US06/247,008 patent/US4367225A/en not_active Expired - Fee Related
-
1982
- 1982-03-03 ZA ZA821422A patent/ZA821422B/xx unknown
- 1982-03-11 IN IN276/CAL/82A patent/IN156510B/en unknown
- 1982-03-23 CS CS822017A patent/CS262407B2/cs unknown
- 1982-03-23 JP JP57044789A patent/JPS5849352A/ja active Granted
-
1987
- 1987-11-11 JP JP62283225A patent/JPS63239297A/ja active Pending
Non-Patent Citations (2)
| Title |
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| JOURNAL OF MEDICAL CHEMISTRY=1978 * |
| JOURNAL OF MEDICAL CHEMISTRY=1980 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61172898A (ja) * | 1985-01-23 | 1986-08-04 | メデイカル カレツジ オブ オハイオ | アルギニンバソプレツシン拮抗薬の新規誘導体類 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS63239297A (ja) | 1988-10-05 |
| CS201782A2 (en) | 1988-08-16 |
| ZA821422B (en) | 1983-04-27 |
| CS262407B2 (en) | 1989-03-14 |
| JPH0325439B2 (en]) | 1991-04-05 |
| US4367225A (en) | 1983-01-04 |
| IN156510B (en]) | 1985-08-17 |
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